Ethyl 2-bromopropionate → HCID 10413093, compound

HRID 620608Notes

Reaction equation

HRID 620608 reaction equation
[C:1]1([CH2:7][O:8][C:9]([NH:11][CH:12]2[N:18]=[C:17]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:16]3[CH:25]=[CH:26][CH:27]=[CH:28][C:15]=3[NH:14][C:13]2=[O:29])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH:31]([CH3:37])[C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[CH2:35]([O:34][C:32](=[O:33])[CH2:31][CH2:37][N:14]1[C:15]2[CH:28]=[CH:27][CH:26]=[CH:25][C:16]=2[C:17]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[N:18][CH:12]([NH:11][C:9]([O:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[O:10])[C:13]1=[O:29])[CH3:36]

Participants

3

Reactant 2

HCID 79040Ethyl 2-bromopropionateHCID 2756242Benzyl (2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)carbamate

Product 1

HCID 10413093HCID 10413093, compound

Procedure

The procedure of Example 134 was carried out using equivalent amounts of 1,3-dihydro-3-phenylmethyloxycarbonylamino-5-phenyl-2H-1,4-benzodiazepin-2-one and ethyl bromopropionate. The product was purified by chromatography on silica gel (hexane-ethyl acetate elution). The combined product fractions were evaporated to dryness in vacuo and crystallized to give the title compound which was dried at 65° C.: m.p. 57°-59° C.

Workup

  1. customThe product was purified by chromatography on silica gel (hexane-ethyl acetate elution)
  2. customThe combined product fractions were evaporated to dryness in vacuo
  3. customcrystallized

Sources & evidence

ORD record
ord-3660f1edf7a84c4ba988ba00214131c0
Source dataset
uspto-grants-1989_04
Patent number
US04820834

Reaction notes

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