Thionyl Chloride → 2-[m-(3-Chloro-2,2,3-trifluoro-propionamido)-phenoxy]-myristoyl chloride

HRID 620701Notes

Reaction equation

HRID 620701 reaction equation
[Cl:1][CH:2]([F:32])[C:3]([F:31])([F:30])[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:27]=[CH:28][CH:29]=1)[O:10][CH:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:12](O)=[O:13])=[O:5].S(Cl)([Cl:35])=O>>[Cl:1][CH:2]([F:32])[C:3]([F:31])([F:30])[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:27]=[CH:28][CH:29]=1)[O:10][CH:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:12]([Cl:35])=[O:13])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 141224182-[m-(3-Chloro-2,2,3-trifluoro-propionamido)-phenoxy]-myristic acid

Product 1

HCID 141224192-[m-(3-Chloro-2,2,3-trifluoro-propionamido)-phenoxy]-myristoyl chloride

Procedure

An amount of 31.5 g of 2-[m-(3-chloro-2,2,3-trifluoro-propionamido)-phenoxy]-myristic acid is refluxed for 30 min with thionyl chloride. The excess thionyl chloride is removed by evaporation. The oil obtained slowly solidifies.

Workup

  1. customThe excess thionyl chloride is removed by evaporation
  2. customThe oil obtained slowly

Sources & evidence

ORD record
ord-c25c14b79c2447a1b79c6d206278d3dc
Source dataset
uspto-grants-1989_04
Patent number
US04822729

Reaction notes

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