反应详情

温度

5 °C

An amount of 843 g (2.1 mol) of 2-(p-nitrophenoxy]-myristoyl chloride is added dropwise in 60 min to a cooled (0°-5° C.) solution of 525 g (2 mol) of 2-benzamido-4-chloro-5-aminophenol in 6 l of tetrahydrofuran and 220 ml of quninoline. The temperature of the reaction mixture is kept below 10° C. The precipitate of quinoline hydrochloride is filtered off. The filtrate is concentrated by evaporation. The residual oil is poured out in 5 l of hot (50° C.) acetonitrile. Upon cooling to 5° C. a precipitate forms, whch is filtered, dried, and recrystallized from boiling isopropyl ether.

1. customis kept below 10° C
2. filtrationThe precipitate of quinoline hydrochloride is filtered off
3. concentrationThe filtrate is concentrated by evaporation
4. additionThe residual oil is poured out in 5 l of hot (50° C.) acetonitrile
5. filtrationis filtered
6. customdried
7. customrecrystallized