Hydrochloric Acid → HCID 13745826, compound

Participants

Reaction Steps

To a solution of 0.73 g of 4-diethoxyphosphinylmethyl-N-(2-methoxycarbonylphenyl)benzamide in 10 ml of ethanol was slowly added 10 ml of 1N sodium hydroxide under ice-cooling with stirring. After stirring for 5 hours at room temperature, 10 ml of 2N hydrochloric acid was added thereto, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated. The crystalline residue was recrystallized from benzene to give 0.60 g of colorless plate crystal of 4-diethoxyphosphinylmethyl-N-(2-carboxyphenyl)benzamide. mp: 171°-172° C.

Provenance & Evidence