Hydrochloric Acid → HCID 13745826, compound

HRID 620721Notes

Reaction equation

HRID 620721 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][C:10]1[CH:28]=[CH:27][C:13]([C:14]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]([O:25]C)=[O:24])=[O:15])=[CH:12][CH:11]=1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].[OH-].[Na+].Cl>C(O)C>[CH2:7]([O:6][P:4]([CH2:9][C:10]1[CH:28]=[CH:27][C:13]([C:14]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]([OH:25])=[O:24])=[O:15])=[CH:12][CH:11]=1)([O:3][CH2:1][CH3:2])=[O:5])[CH3:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13745827HCID 13745827, compound

Product 1

HCID 13745826HCID 13745826, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.73 g of 4-diethoxyphosphinylmethyl-N-(2-methoxycarbonylphenyl)benzamide in 10 ml of ethanol was slowly added 10 ml of 1N sodium hydroxide under ice-cooling with stirring. After stirring for 5 hours at room temperature, 10 ml of 2N hydrochloric acid was added thereto, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated. The crystalline residue was recrystallized from benzene to give 0.60 g of colorless plate crystal of 4-diethoxyphosphinylmethyl-N-(2-carboxyphenyl)benzamide. mp: 171°-172° C.

Workup

  1. temperaturecooling
  2. stirringAfter stirring for 5 hours at room temperature
  3. extractionthe mixture was extracted with chloroform
  4. dry with materialThe extract was dried over anhydrous sodium sulfate
  5. customthe solvent was evaporated
  6. customThe crystalline residue was recrystallized from benzene

Sources & evidence

ORD record
ord-c9cfbc29e2ee43ff82869f932ee1b0c0
Source dataset
uspto-grants-1989_04
Patent number
US04822780

Reaction notes

Loading…