Chloroform → HCID 21245049, compound

HRID 620726Notes

Reaction equation

HRID 620726 reaction equation
[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]1[CH:10](O)[CH2:11][O:12][CH3:13])[CH2:2][CH3:3].C(Cl)(Cl)[Cl:16].S(Cl)(Cl)=O>ClCl>[CH2:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]1[CH:10]([Cl:16])[CH2:11][O:12][CH3:13])[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 21245051HCID 21245051, compound

Product 1

HCID 21245049HCID 21245049, compound

Reagents, catalysts & solvents 1

HCID 24526ChlorineSolvent

Procedure

In a first stage, 32 g (0.16 mol) of 1-propyl-2-(α-hydroxy-β-methoxyethyl)piperidine were introduced into a reactor containing 320 ml of anhydrous chloroform, the mixture was brought to 50° C. and 32 ml of thionyl chloride in 32 ml of chlorine were added dropwise, and the mixture was then heated under reflux for 10 h 30 min. After separation and distillation, 24.25 g of 1-propyl-2-(α-chloro-β-methoxyethyl)piperidine were obtained, of boiling point B.p.0.5 95° C.

Workup

  1. customwas brought to 50° C.
  2. temperaturethe mixture was then heated
  3. temperatureunder reflux for 10 h 30 min
  4. customAfter separation and distillation

Sources & evidence

ORD record
ord-29bf14e893a94c7e8ea7d6c887164747
Source dataset
uspto-grants-1989_04
Patent number
US04822792

Reaction notes

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