Chloroform → HCID 21245049, compound

Participants

Reaction Steps

In a first stage, 32 g (0.16 mol) of 1-propyl-2-(α-hydroxy-β-methoxyethyl)piperidine were introduced into a reactor containing 320 ml of anhydrous chloroform, the mixture was brought to 50° C. and 32 ml of thionyl chloride in 32 ml of chlorine were added dropwise, and the mixture was then heated under reflux for 10 h 30 min. After separation and distillation, 24.25 g of 1-propyl-2-(α-chloro-β-methoxyethyl)piperidine were obtained, of boiling point B.p.0.5 95° C.

Provenance & Evidence