Methanesulfonyl chloride → 7-Methanesulphonamido-3-(6-methanesulphonamidoquinol-2-ylmethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine

HRID 620729Notes

Reaction equation

HRID 620729 reaction equation
[NH2:1][C:2]1[CH:24]=[CH:23][C:5]2[CH2:6][CH2:7][N:8]([CH2:11][C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([NH2:22])[CH:18]=4)[N:13]=3)[CH2:9][CH2:10][C:4]=2[CH:3]=1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>N1C=CC=CC=1>[CH3:25][S:26]([NH:1][C:2]1[CH:24]=[CH:23][C:5]2[CH2:6][CH2:7][N:8]([CH2:11][C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([NH:22][S:26]([CH3:25])(=[O:28])=[O:27])[CH:18]=4)[N:13]=3)[CH2:9][CH2:10][C:4]=2[CH:3]=1)(=[O:28])=[O:27]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 212450547-amino-3-(6-aminoquinol-2-ylmethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine

Product 1

HCID 212450577-Methanesulphonamido-3-(6-methanesulphonamidoquinol-2-ylmethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound, m.p. 207°-210°, was prepared similarly to the procedure of Example 1 starting from 7-amino-3-(6-aminoquinol-2-ylmethyl)-1,2,4,5-tetrahydro-3H-3-benzazepine and methanesulphonyl chloride in pyridine.

Sources & evidence

ORD record
ord-b6bb0e42d0e0426a828f660ac9eaa06e
Source dataset
uspto-grants-1989_04
Patent number
US04822793

Reaction notes

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