2-Mercaptoethanol → HCID 14551711, compound

Participants

Reaction Steps

A mixture of 26 g (0.14 mole) of 3,5-dichloro-2-heptanone, 12 g (0.15 mole) of 2-mercaptoethanol, and 15 g (0.15 mole) of triethylamine in 200 ml toluene, was stirred at ambient temperature overnight. The mixture was then washed with dilute hydrochloric acid and subsequently refluxed with 0.1 g. p-toluenesulfonic acid with azeotropic removal of water for six hours. Upon cooling, it was washed with aqueous sodium bicarbonate, dried (magnesium sulfate), and the solvent was removed to leave the product.

Provenance & Evidence