反应详情

A mixture of 26 g (0.14 mole) of 3,5-dichloro-2-heptanone, 12 g (0.15 mole) of 2-mercaptoethanol, and 15 g (0.15 mole) of triethylamine in 200 ml toluene, was stirred at ambient temperature overnight. The mixture was then washed with dilute hydrochloric acid and subsequently refluxed with 0.1 g. p-toluenesulfonic acid with azeotropic removal of water for six hours. Upon cooling, it was washed with aqueous sodium bicarbonate, dried (magnesium sulfate), and the solvent was removed to leave the product.

1. washThe mixture was then washed with dilute hydrochloric acid
2. temperaturesubsequently refluxed with 0.1 g
3. customp-toluenesulfonic acid with azeotropic removal of water for six hours
4. temperatureUpon cooling
5. washit was washed with aqueous sodium bicarbonate
6. dry with materialdried (magnesium sulfate)
7. customthe solvent was removed
8. customto leave the product