反应详情

A solution of 2-[4-(N-acetyl-N-methylamino)-5-chloro-2-methoxyphenyl]-4-methyl-5-(3-pyridyl)imidazole (0.70 g) and conc. hydrochloric acid (7 ml) in a mixture of water (7 ml) and ethanol (7 ml) was refluxed for 7 hours with stirring. After allowed to cool to ambient temperature, the mixture was evaporated under reduced pressure. The resulting oil was poured into water (20 ml). After neutrallized with aqueous potassium bicarbonate the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over magnesium sulfate. The solvent was distilled off to give 2-(5-chloro-4-methylamino-2-methoxyphenyl)-4-methyl-5-(3-pyridyl)imidazole (0.58 g).

1. temperaturewas refluxed for 7 hours
2. customthe mixture was evaporated under reduced pressure
3. additionThe resulting oil was poured into water (20 ml)
4. extractionwas extracted with ethyl acetate
5. washThe organic layer was washed with brine
6. dry with materialdried over magnesium sulfate
7. distillationThe solvent was distilled off