Methyl isothiocyanate → HCID 178486099, compound

HRID 620843Notes

Reaction equation

HRID 620843 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:9][C:10]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[C:11]([CH3:13])[N:12]=1.[CH3:20][N:21]=[C:22]=[S:23]>O1CCCC1>[CH3:13][C:11]1[N:12]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:22]([NH:21][CH3:20])=[S:23])[NH:9][C:10]=1[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 178432492HCID 178432492, compound

Product 1

HCID 178486099HCID 178486099, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(2-aminophenyl)-4-methyl-5-(3-pyridyl)imidazole (0.8 g) in tetrahydrofuran (10 ml) was added methyl isothiocyanate (0.33 ml) at ambient temperature. The reaction mixture was stirred at ambient temperature for one hour, and refluxed for 20 hours. The resulting precipitate was collected by filtration, and washed with tetrahydrofuran and diethyl ether to give 4-methyl-2-[2-(3-methylthioureido)phenyl]-5-(3-pyridyl)imidazole (0.71 g).

Workup

  1. temperaturerefluxed for 20 hours
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with tetrahydrofuran and diethyl ether

Sources & evidence

ORD record
ord-c7811a614a3847ddba50c3e586fe871a
Source dataset
uspto-grants-1989_04
Patent number
US04822805

Reaction notes

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