Toluene → 1-tert-Butyl-2,5-dichloro-4-methylbenzene

HRID 620958Notes

Reaction equation

[Cl-:1].[Al+3].[Cl-:3].[Cl-].[C:5]1([CH3:11])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>>[Cl:1][C:6]1[CH:7]=[C:8]([C:5]([CH3:11])([CH3:10])[CH3:6])[C:9]([Cl:3])=[CH:10][C:5]=1[CH3:11]

Participants

Reactant 2

HCID 1140Toluene

HCID 6451240Aluminum(III) Chloride

Product 1

HCID 144188301-tert-Butyl-2,5-dichloro-4-methylbenzeneYield 270.8%

Procedure

After adding a large excess of 2000 g of toluene and 64 g (0.48 mol) of anhydrous aluminum chloride, as a catalyst, to 284 g (1.3 mol) of 2,5-dichloro-4-t-butyltoluene obtained as stated above, the mixture was brought into reaction for 5 hours at room temperature under a vigorous agitation thereof.

Sources & evidence

ORD record: ord-7d240177babf4591935d6a2ff34f315a
Source dataset: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04822928

Reaction notes

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