Hydrochloric Acid → HCID 19903102, compound

HRID 621183Notes

Reaction equation

HRID 621183 reaction equation
C([O:8][C:9](=[O:38])[CH2:10][N:11]([C:21](=[O:37])[CH2:22][N:23]([CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])CC1C=CC=CC=1)[CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1)C1C=CC=CC=1.[H][H].[ClH:41].CCOCC>C(O)C.[C].[Pd]>[ClH:41].[CH2:35]([O:34][C:32]([CH2:31][NH:23][CH2:22][C:21]([N:11]([CH:12]1[CH2:13][C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:20]1)[CH2:10][C:9]([OH:38])=[O:8])=[O:37])=[O:33])[CH3:36]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 19903086HCID 19903086, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19903102HCID 19903102, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

N-(N'-Ethoxycarbonylmethyl-N'-benzylglycyl)-N-(indan-2-yl)glycine benzyl ester (3 g) is dissolved in 100 ml of ethanol, and catalytic reduction is carried out at ordinary temperature and pressure using 5% palladium-carbon as catalyst. After absorption of 2 equivalents of hydrogen, the reaction mixture is filtered to remove the catalyst. The ethanol is distilled off under reduced pressure to give an oily substance. Addition of ethanolic hydrochloric acid with 100 ml of ether to the oily substance gives N-(N'-ethoxycarbonylmethylglycyl)-N-(indan-2-yl)glycine hydrochloride as colorless powder.

Workup

  1. filtrationthe reaction mixture is filtered
  2. customto remove the catalyst
  3. distillationThe ethanol is distilled off under reduced pressure
  4. customto give an oily substance

Sources & evidence

ORD record
ord-2bce1259c7e14da791a7795e2a104c34
Source dataset
uspto-grants-1989_04
Patent number
US04822818

Reaction notes

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