Isopropyl isocyanate → HCID 21242494, compound

HRID 621377Notes

Reaction equation

HRID 621377 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:9]2[NH:13][CH2:12][CH:11]([CH2:14][CH3:15])[O:10]2)[CH:6]=[CH:7][CH:8]=1.[CH:18]([N:21]=[C:22]=[O:23])([CH3:20])[CH3:19]>CC(C)=O>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:4]=[C:5]([CH:9]2[N:13]([C:22](=[O:23])[NH:21][CH:18]([CH3:20])[CH3:19])[CH2:12][CH:11]([CH2:14][CH3:15])[O:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 212424932-(m-Trifluoromethylphenyl)-5-ethyl-1,3-oxazolidine

Product 1

HCID 21242494HCID 21242494, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Four and four-tenths grams of 2-(m-trifluoromethylphenyl)-5-ethyl-1,3-oxazolidine was dissolved in dry acetone and 1.8 ml of isopropyl isocyanate was added dropwise. The mixture was heated at reflux for two hours, cooled and stripped on the rotary evaporator. Yield was 5.9 g of a thick, sticky gum. The structure was confirmed by NMR and infrared spectroscopy.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for two hours
  3. temperaturecooled
  4. customstripped on the rotary evaporator

Sources & evidence

ORD record
ord-a587f56712134915a3b015193bb88f55
Source dataset
uspto-grants-1989_04
Patent number
US04824468

Reaction notes

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