Water → HCID 21242492, compound

HRID 621379Notes

Reaction equation

HRID 621379 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:9]2[NH:13][CH2:12][CH:11]([CH2:14][CH3:15])O2)[CH:6]=[CH:7][CH:8]=1.N1[CH:23]=[CH:22][CH:21]=CC=1.[OH-:24].[Na+].[OH2:26].[CH2:27](Cl)Cl>ClC(OC(C)C)=O>[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:9]2[N:13]([C:27]([CH:22]([CH3:21])[CH3:23])=[O:26])[CH2:12][CH:11]([CH2:14][CH3:15])[O:24]2)[CH:6]=[CH:7][CH:8]=1

Participants

7

Reactant 5

HCID 962WaterHCID 1049PyridineHCID 6344Dichloromethane2×HCID 14798Sodium HydroxideHCID 212424932-(m-Trifluoromethylphenyl)-5-ethyl-1,3-oxazolidine

Product 1

HCID 21242492HCID 21242492, compound

Reagents, catalysts & solvents 1

HCID 7917Isopropyl chloroformateSolvent

Procedure

Four and four-tenths grams of 2-(m-trifluoromethylphenyl)-5-ethyl-1,3-oxazolidine was combined with 1.5 g of pyridine in 25 ml of methylene chloride and 2.1 ml of isopropyl chloroformate in 10 ml of methylene chloride was added with stirring. The mixture was left to stir overnight. It was worked up with 50 ml of 5% NaOH and 200 ml of water, dried with anhydrous MgSO4 and stripped under vacuum on the rotary evaporator. The structure was confirmed by NMR and infrared spectroscopy.

Workup

  1. additionwas added
  2. waitThe mixture was left
  3. stirringto stir overnight
  4. dry with materialdried with anhydrous MgSO4
  5. customstripped under vacuum on the rotary evaporator

Sources & evidence

ORD record
ord-2f58b58641424efb9583af84a5f48a9e
Source dataset
uspto-grants-1989_04
Patent number
US04824468

Reaction notes

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