反应详情

This trans-4-pentylcyclohexanecarboxamidine hydrochloride (69 g, 0.30 mol) and dimethyl methoxymalonate (48 g, 0.30 mol) were added to a solution of sodium methylate (56 g, 1.0 mol) dissolved in anhydrous methanol (1 l), followed by heating the mixture under reflux with stirring for 5 hours, thereafter cooling the resulting material, mixing it with 6N-hydrochloric acid (500 ml), agitating the mixed liquid at room temperature for 20 minutes, filtering the liquid under suction through a filter, washing the resulting residue on the filter with water and methanol and drying it under reduced pressure to obtain 2-(trans-4-pentylcyclohexyl)-4,6-dihydroxy-5-methoxypyrimidine (67 g, 0.23 mol).

1. temperatureby heating the mixture
2. temperatureunder reflux
3. temperaturecooling the resulting material
4. stirringagitating the mixed liquid at room temperature for 20 minutes
5. filtrationfiltering the liquid under suction through a filter
6. washwashing the resulting residue on the
7. filtrationfilter with water and methanol
8. customdrying it under reduced pressure