反应详情

温度

25 °C

3 g. (14.7 mMole) 7-amino-4,4-dimethylisoquinoline-1,3-dione were dissolved in 100 ml. methylene chloride, mixed with 5 ml. methyl isocyanate, while cooling, and then further stirred for 2 hours at 25° C. Subsequently, the reaction mixture was evaporated, cooled, filtered off with suction and recrystallised from methanol. Yield: 3.7 g. (96.4% of theory); m.p. 257°-258° C.

1. customSubsequently, the reaction mixture was evaporated
2. temperaturecooled
3. filtrationfiltered off with suction
4. customrecrystallised from methanol