HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 621417Generated: October 25, 2026
Methyl Isocyanate → N-Methyl-N'-(4,4-dimethyl-1,2,3,4-tetrahydro-1,3-dioxo-7-isoquinolinyl)-urea
https://huagongshe.com/reaction/621417
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 7-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dione | HCID 13558151 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Methyl-N'-(4,4-dimethyl-1,2,3,4-tetrahydro-1,3-dioxo-7-isoquinolinyl)-urea | HCID 10445362 | — |
Reaction Steps
3 g. (14.7 mMole) 7-amino-4,4-dimethylisoquinoline-1,3-dione were dissolved in 100 ml. methylene chloride, mixed with 5 ml. methyl isocyanate, while cooling, and then further stirred for 2 hours at 25° C. Subsequently, the reaction mixture was evaporated, cooled, filtered off with suction and recrystallised from methanol. Yield: 3.7 g. (96.4% of theory); m.p. 257°-258° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04824835 |
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| Source dataset | uspto-grants-1989_04 |
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| ORD ID | ord-ee1c2ab484464526bb4d5008061dde8a |
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| Source note | uspto-grants-1989_04 |
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