Hydrochloric Acid → 8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

HRID 621436Notes

Reaction equation

HRID 621436 reaction equation
C([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([O:19][CH3:20])[C:13]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:14][C:7]=2[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][O:19][C:12]1[C:13]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:14][C:7]2[CH2:6][CH2:5][NH:4][CH2:10][CH2:9][C:8]=2[CH:11]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 138533513-acetyl-8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 212428978-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Procedure

The sulfonamide (2.3 g, 0.007 m) was suspended in 3N hydrochloric acid and heated to reflux for 16 hours. The mixture was concentrated in vacuo and the residue crystallized from methanol to give 8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, m.p. 270°-274°.

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe mixture was concentrated in vacuo
  4. customthe residue crystallized from methanol

Sources & evidence

ORD record
ord-94000b9c25bf458f80503ac3986a23fa
Source dataset
uspto-grants-1989_04
Patent number
US04824839

Reaction notes

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