Hydrogen Bromide → 8-hydroxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

HRID 621437Notes

Reaction equation

HRID 621437 reaction equation
Cl.C[O:3][C:4]1[C:5]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:6][C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[CH:14]=1.[BrH:19]>>[BrH:19].[OH:3][C:4]1[C:5]([S:15](=[O:17])(=[O:18])[NH2:16])=[CH:6][C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[CH:14]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 212428978-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Product 1

HCID 212429058-hydroxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Procedure

8-Methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (1.5 g, 0.005 m) was dissolved in 48% hydrobromic acid (15 ml), refluxed for 2 hours and concentrated in vacuo. The residue was triturated with acetone and then recrystallized from methanol to give 8-hydroxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, m.p. 315°-320° (decomp.).

Workup

  1. temperaturerefluxed for 2 hours
  2. concentrationconcentrated in vacuo
  3. customThe residue was triturated with acetone
  4. customrecrystallized from methanol

Sources & evidence

ORD record
ord-1c48a064641a4383afd3c802c78c9852
Source dataset
uspto-grants-1989_04
Patent number
US04824839

Reaction notes

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