Hydrochloric Acid → 8-methoxy-7-(N-methylsulfamoyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

HRID 621438노트

반응식

HRID 621438 반응식
C([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([O:19][CH3:20])[C:13]([S:15]([Cl:18])(=[O:17])=[O:16])=[CH:14][C:7]=2[CH2:6][CH2:5]1)(=O)C.Cl.[CH3:22][NH2:23]>>[ClH:18].[CH3:20][O:19][C:12]1[C:13]([S:15](=[O:17])(=[O:16])[NH:23][CH3:22])=[CH:14][C:7]2[CH2:6][CH2:5][NH:4][CH2:10][CH2:9][C:8]=2[CH:11]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 138533503-acetyl-7-chlorosulfonyl-8-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine

생성물 1

HCID 212429348-methoxy-7-(N-methylsulfamoyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

실험 절차

3-Acetyl-7-chlorosulfonyl-8-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine (2 g) was stirred with 10 ml of 40% aqueous methylamine, then was treated with hydrochloric acid and concentrated in vacuo to give 8-methoxy-7-(N-methylsulfamoyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride. This 8-methoxy-7-(N-methylsulfamoyl) compound was treated with boron tribromide in methylene chloride and then with methanol to give 8-hydroxy-7-(N-methylsulfamoyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, m.p. 130°-135° C.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f0eacb66dcbf466888271cd38fb27f57
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824839

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