反应详情

3-Acetyl-8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (1 g, 0.003 m), prepared as in Method A or B, in 48% hydrobromic acid (15 ml) was heated to reflux for 16 hours and concentrated in vacuo. The residue was triturated with acetone and recrystallized from methanol-water to give 8-hydroxy-7-methylsulfonyl-2.3.4.5 -tetrahydro-1H-3-benzazepine hydrobromide, m.p. 300° (decomp.).

1. temperatureto reflux for 16 hours
2. concentrationconcentrated in vacuo
3. customThe residue was triturated with acetone
4. customrecrystallized from methanol-water