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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 621458Generated: November 4, 2026

Hydrochloric Acid → 7-methanesulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

https://huagongshe.com/reaction/621458

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant2,3,4,5-Tetrahydro-1H-benzo(d)azepineHCID 1400243—
Reactant3-Acetyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 11265634—
Reactant3-acetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonyl chlorideHCID 11346737—
Product7-methanesulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochlorideHCID 21242879—

Reaction Steps

Following the procedure of Examples 1 and 4, 2,3,4,5-tetrahydro-1H-3-benzazepine was converted to 3-acetyl-7-chlorosulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine and then to 3-acetyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine which was hydrolyzed with hydrochloric acid to give 7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, m.p. 275°-277° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04824839
Source datasetuspto-grants-1989_04
ORD IDord-fd83b138521e4376a4f73a18e9b7c44c
Source noteuspto-grants-1989_04