Methanol → HCID 178456466, compound

HRID 621478Notes

Reaction equation

HRID 621478 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][N:6]1[C:13]([NH:14][NH:15][C:16]([NH:18][CH3:19])=S)=[CH:12][C:10](=[O:11])[N:9]([CH2:20][CH2:21][CH3:22])[C:7]1=[O:8].CO>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:23]=[CH:24][CH:25]=1)[CH2:5][N:6]1[C:13]2[NH:14][N:15]=[C:16]([NH:18][CH3:19])[C:12]=2[C:10](=[O:11])[N:9]([CH2:20][CH2:21][CH3:22])[C:7]1=[O:8]

Participants

4

Reactant 2

HCID 887MethanolHCID 14100220HCID 14100220, compound

Product 1

HCID 178456466HCID 178456466, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-(3-chlorobenzyl)-6-(4-methylthiosemicarbazido)-3-propyluracil (3.81 g, 10 mM) in DMF (40 ml) was stirred at 100° C. for 20 hours. To the reaction solution was added 50% methanol (20 ml) and the mixture was cooled to give crystals. Recrystallization from DMF/methanol gave colorless crystals (2.49 g, 72%), m.p. 263°-265° C.

Workup

  1. temperaturethe mixture was cooled
  2. customto give crystals
  3. customRecrystallization from DMF/methanol

Sources & evidence

ORD record
ord-b820ad6fcb4a4564a14669f93bf9b999
Source dataset
uspto-grants-1989_04
Patent number
US04824848

Reaction notes

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