Methanol → HCID 178456467, compound

HRID 621479Notes

Reaction equation

HRID 621479 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:14]([NH:15][NH:16][C:17]([NH:19][CH3:20])=S)=[CH:13][C:11](=[O:12])[N:10]([CH2:21][CH2:22][CH3:23])[C:8]2=[O:9])=[CH:4][CH:3]=1.CO>CN(C=O)C>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][N:7]2[C:14]3[NH:15][N:16]=[C:17]([NH:19][CH3:20])[C:13]=3[C:11](=[O:12])[N:10]([CH2:21][CH2:22][CH3:23])[C:8]2=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 21243185HCID 21243185, compound

Product 1

HCID 178456467HCID 178456467, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-(4-chlorobenzyl)-6-(4-methylthiosemicarbazido)-3-propyluracil (4.8 g, 12.6 mM) in DMF (50 ml) was stirred at 100° C. for 40 hours. To the solution was added 50% methanol (20 ml) and the mixture was cooled to give crystals. Recrystallization from DMF/methanol gave colorless crystals (2.8 g, 50%), m.p. 305°-307° C.

Workup

  1. temperaturethe mixture was cooled
  2. customto give crystals
  3. customRecrystallization from DMF/methanol

Sources & evidence

ORD record
ord-a5fe4ab32c6649538fcd2bae43f57570
Source dataset
uspto-grants-1989_04
Patent number
US04824848

Reaction notes

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