Methyl iodide → 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione

HRID 621521Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 621521
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:16][C:15](=[O:17])[NH:14][C:13](=[O:18])[CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[OH-].[K+].[CH3:21]I>O.CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:16][C:15](=[O:17])[N:14]([CH3:21])[C:13](=[O:18])[CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Komponenten

6

Edukt 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 212432066-(3,4-dimethoxyphenyl)-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 137142586-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a suspension of 6-(3,4-dimethoxyphenyl)-2,4(1H,3H)-pyrimidinedione (1.0 g) in a mixture of water (5 ml) and methanol (5 ml) was added potassium hydroxide (0.57 g), and to an almost dissolved mixture was added methyl iodide (5 ml). The mixture was stirred at ambient temperature for 18 hours. The resulting precipitates were filtered and washed successively with water, ethanol and diisopropyl ether to afford 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione (0.13 g).

Aufarbeitung

  1. customThe resulting precipitates
  2. filtrationwere filtered
  3. washwashed successively with water, ethanol and diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-154dcd435c4d4006a9ce67a241fa1959
Quelldatensatz
uspto-grants-1989_04
Patentnummer
US04824851

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