反应详情

To a suspension of 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1-ethyl-3-methyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone (11.3 g) in water (20 ml) was added conc. hydrochloric acid (3.1 ml) and the mixture was evaporated under reduced pressure. To the residue was added ethanol (20 ml) and evaporated under reduced pressure again. The residue was crystallized from a mixture of diisopropyl ether and methanol (1:1) to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1-ethyl-3-methyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone hydrochloride (9.9 g).

1. customthe mixture was evaporated under reduced pressure
2. additionTo the residue was added ethanol (20 ml)
3. customevaporated under reduced pressure again
4. customThe residue was crystallized from a mixture of diisopropyl ether and methanol (1:1)