Hydrochloric Acid → HCID 12899415, compound

HRID 621545Notes

Reaction equation

HRID 621545 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C(=O)C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12899414HCID 12899414, compound

Product 1

HCID 12899415HCID 12899415, compoundYield 78.2%

Procedure

The thus-obtained 21 g of 8-bromo-5-acetyloxy-3,4-dihydrocarbostyril are dispersed in 150 ml of 8N-hydrochloric acid. The dispersion is heated under reflux conditions for 3 hours and then cooled. The insoluble matter thus formed is separated by filtration, washed with water and dried, and recrystallized from methanol-water to obtain 14 g of 8-bromo-5-hydroxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals with a melting point of 212°-213° C.

Workup

  1. temperatureThe dispersion is heated under reflux conditions for 3 hours
  2. temperaturecooled
  3. customThe insoluble matter thus formed
  4. customis separated by filtration
  5. washwashed with water
  6. customdried
  7. customrecrystallized from methanol-water

Sources & evidence

ORD record
ord-bcb1ac2323eb437aaf6c5a5e6f00ce41
Source dataset
uspto-grants-1989_04
Patent number
US04824840

Reaction notes

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