Hydrochloric Acid → HCID 12899522, compound

HRID 621570Notes

Reaction equation

HRID 621570 reaction equation
C([O:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:18]=2[CH2:19][CH2:20][C:21](=[O:27])[NH:22]3)[CH2:9][CH2:8]1)(=O)C.Cl>CO>[OH:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:18]=2[CH2:19][CH2:20][C:21](=[O:27])[NH:22]3)[CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12899521HCID 12899521, compound

Product 1

HCID 12899522HCID 12899522, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.0 grams of 5-{3-[4-(2-acetyloxyethyl)-piperazinyl]propoxy}-3,4-dihydrocarbostyril are mixed with 30 ml of methanol and 5 ml of concentrated hydrochloric acid and heated for 2 hours under refluxing conditions. The reaction mixture is concentrated under reduced pressure to dryness. The residue is recrystallized from water to obtain 5-{3-[4-(2-hydroxyethyl)piperazinyl]propoxy}-3,4-dihydrocarbostyril in the form of colorless flake-like crystals with a melting point of 158°-159° C.

Workup

  1. temperatureheated for 2 hours under refluxing conditions
  2. concentrationThe reaction mixture is concentrated under reduced pressure to dryness
  3. customThe residue is recrystallized from water

Sources & evidence

ORD record
ord-4e0755b4563c425b8bf68c754e794148
Source dataset
uspto-grants-1989_04
Patent number
US04824840

Reaction notes

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