HCID 12899539, compound → HCID 14128502, compound

HRID 621575Notes

Reaction equation

HRID 621575 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:27]=[CH:26][CH:25]=[C:24]3[C:19]=2[CH2:20][CH2:21][C:22](=[O:28])[NH:23]3)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)(C)C>[N:11]1([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:27]=[CH:26][CH:25]=[C:24]3[C:19]=2[CH2:20][CH2:21][C:22](=[O:28])[NH:23]3)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 12899539HCID 12899539, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14128502HCID 14128502, compoundYield 107.5%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

(a)-2 5 grams of 5-[3-(4-benzylpiperazinyl)propoxy]-3,4-dihydrocarbostyril and 0.8 g of 5%-Pd charcoal are added into 150 ml of isopropanol and catalytically reduced at 60° C. for 5 hours under 3 atm. of hydrogen gas pressure. The catalyst is removed by filtration and the mother liquor thus obtained is concentrated under reduced pressure. The residue is recrystallized from ligroin-benzene to obtain 4.1 g of 5-(3-piperazinylpropoxy)-3,4-dihydrocarbostyril in the form of colorless prism-like crystals having a melting point of 195°-196° C.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe mother liquor thus obtained
  3. concentrationis concentrated under reduced pressure
  4. customThe residue is recrystallized from ligroin-benzene

Sources & evidence

ORD record
ord-7600390201a44b84a2d491bbf7151387
Source dataset
uspto-grants-1989_04
Patent number
US04824840

Reaction notes

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