反应详情

37.4 g of 2-[4-(5-hydroxymethyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine are dissolved in 1.6 l of THF, and 300 ml of ether are added. While stirring, 55 g of MnO2 are added. The mixture is stirred at 20° for 16 hours, a further 100 g of MnO2 are added in portions, and the mixture is stirred at 20° for a further 100 hours. After filtration and the usual working up, 2-[4-(5-formyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine is obtained.

1. stirringThe mixture is stirred at 20° for 16 hours
2. stirringthe mixture is stirred at 20° for a further 100 hours
3. filtrationAfter filtration