Phenidone → Stk037974

HRID 621591Notes

Reaction equation

HRID 621591 reaction equation
[C:1]1([N:7]2[CH2:11][CH2:10][C:9](=O)[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[Cl:15][C:9]1[CH2:10][CH2:11][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=1

Participants

4

Reactant 2

HCID 7090PhenidoneHCID 24813Phosphorus oxychloride

Product 1

HCID 787909Stk037974

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

1-Phenylpyrazolidin-3-one (8.1 g) was suspened in dry toluene (100 ml), followed by addition of phosphoryl chloride (7.0 ml) and the mixture stirred for 1 hour at 85° . When cool the toluene was decanted from the solid and solvent removed in vacuo to give the sub-title compound, (6.9 g), mp 92°-93°.

Workup

  1. customwas decanted from the solid and solvent
  2. customremoved in vacuo

Sources & evidence

ORD record
ord-30f0ac8d135b466faf084678c9c1706c
Source dataset
uspto-grants-1989_04
Patent number
US04824859

Reaction notes

Loading…