Hydrochloric Acid → 4-Chloro-16alpha-fluoro-1,6beta-dimethyl-7-methylen-androsta-1,4-diene-3,17-dione

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Reaction Steps

A solution of 4,5-epoxy-16α-fluoro-1,6β-dimethyl-7-methylenandrost-1-ene-3,17-dione (359 mg) in glacial acetic acid (5 ml) is treated with gaseous hydrogen chloride for about 30 min at room temperature. The precipitate is filtered off, washed with diethylether and then chromatographed on silica gel to give pure 4-chloro-16α-fluoro-1,6β-dimethyl-7-methylen-androsta-1,4-diene-3,17-dione (245 mg).

Provenance & Evidence