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HRID621628

反应详情

EQUATION

反应方程式

HRID 621628 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：C=C1[C@H]2[C@@H]3C[C@@H](F)C(=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)C(C)=CC(=O)C3OC32[C@@H]1C
HCID18632049

未命名化合物

PRODUCTS

生成物

1
结构：C=C1[C@@H](C)C2=C(Cl)C(=O)C=C(C)[C@]2(C)[C@H]2CC[C@]3(C)C(=O)[C@H](F)C[C@H]3[C@H]12
HCID18632051

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

A solution of 4,5-epoxy-16α-fluoro-1,6β-dimethyl-7-methylenandrost-1-ene-3,17-dione (359 mg) in glacial acetic acid (5 ml) is treated with gaseous hydrogen chloride for about 30 min at room temperature. The precipitate is filtered off, washed with diethylether and then chromatographed on silica gel to give pure 4-chloro-16α-fluoro-1,6β-dimethyl-7-methylen-androsta-1,4-diene-3,17-dione (245 mg).

WORKUP

后处理

  1. filtrationThe precipitate is filtered off
  2. washwashed with diethylether
  3. customchromatographed on silica gel