Sodium Chloride → HCID 19934656, compound

HRID 621634Notes

Reaction equation

HRID 621634 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([O:16][CH3:17])[CH:4]=1.[C-:18]#[N:19].[Na+].[Cl-].[Na+]>CN(C)C=O>[C:18]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([O:16][CH3:17])[CH:4]=1)#[N:19]

Participants

5

Reactant 3

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 19934631HCID 19934631, compound

Product 1

HCID 19934656HCID 19934656, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
30 °C

Procedure

The 1-chloromethyl-3-methoxy-4-phenylthiobenzene obtained above is dissolved in N,N-dimethylformamide (200 ml), and thereto is added finely divided sodium cyanide (7.34 g), and the mixture is stirred at 30° C. for 14 hours. To the reaction mixture are added saturated aqueous sodium chloride solution (300 ml) and ice water (300 ml), and the mixture is extracted with ethyl acetate (300 ml×3). The combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3) and dried over anhydrous sodium sulfate to give 1-cyanomethyl-3-methoxy-4-phenylthiobenzene. benzene.

Workup

  1. extractionthe mixture is extracted with ethyl acetate (300 ml×3)
  2. washThe combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3)
  3. dry with materialdried over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-61188dab6b6a41dea3e4c1e5783cfd8a
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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