反应详情

To a suspension of sodium methoxide (5.56 g) in benzene (200 ml) is added dropwise with stirring a mixture of ethyl formate (8.14 g) and phenylacetonitrile (11.7 g) under ice cooling. After 30 minutes, the ice bath is taken off. After reacting for 3 hours, ice water is added to the reaction mixture, and the aqueous layer is separated. The organic layer is washed with 0.5 N sodium hydroxide solution (50 ml×3), and the aqueous layer and the washings are combined and adjusted to pH 3-4 with conc. hydrochloric acid. The mixture is stirred under ice cooling for 20 minutes, and the resulting precipitate is separated by filtration and washed with water to give α-formylphenylacetonitrile. The product is used in the subsequent procedure without further purification.

1. additionis added dropwise
2. waitAfter reacting for 3 hours
3. customthe aqueous layer is separated
4. washThe organic layer is washed with 0.5 N sodium hydroxide solution (50 ml×3)
5. stirringThe mixture is stirred under ice cooling for 20 minutes
6. customthe resulting precipitate is separated by filtration
7. washwashed with water