反应详情

4-Hydroxy-8-(4-nitrophenyl)pyrazolo[1,5-a]-1,3,5-triazine (660 mg) and 5% palladium-carbon (500 mg) are suspended in 80% aqueous methanol (100 ml), and the mixture is stirred under hydrogen atmosphere at room temperature. After reacting for 46 hours, to the reaction mixture is added conc. hydrochloric acid (5 ml), and the insoluble material is removed off by filtration. The filtrate is concentrated to driness under reduced pressure to give the title compound (450 mg).

1. customthe insoluble material is removed off by filtration
2. concentrationThe filtrate is concentrated to driness under reduced pressure