Hydrochloric Acid → HCID 178507420, compound

HRID 621652Notes

Reaction equation

HRID 621652 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)=[C:6]2[N:5]=[CH:4][N:3]=1.Cl>CO.[C].[Pd]>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[CH:9]=[N:8][N:7]3[C:2]([OH:1])=[N:3][CH:4]=[N:5][C:6]=23)=[CH:12][CH:13]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178526531HCID 178526531, compound

Product 1

HCID 178507420HCID 178507420, compoundYield 77.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

4-Hydroxy-8-(4-nitrophenyl)pyrazolo[1,5-a]-1,3,5-triazine (660 mg) and 5% palladium-carbon (500 mg) are suspended in 80% aqueous methanol (100 ml), and the mixture is stirred under hydrogen atmosphere at room temperature. After reacting for 46 hours, to the reaction mixture is added conc. hydrochloric acid (5 ml), and the insoluble material is removed off by filtration. The filtrate is concentrated to driness under reduced pressure to give the title compound (450 mg).

Workup

  1. customthe insoluble material is removed off by filtration
  2. concentrationThe filtrate is concentrated to driness under reduced pressure

Sources & evidence

ORD record
ord-ab77d00ffc3e486180cc95a0787f5884
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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