Acetyl chloride → HCID 67797825, compound

HRID 621657Notes

Reaction equation

HRID 621657 reaction equation
[OH:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[S:12][CH:13]=[C:14]([CH3:17])[C:15]=3[CH3:16])=[C:6]2[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[C:25](Cl)(=[O:27])[CH3:26]>C(Cl)Cl>[C:25]([O:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[S:12][CH:13]=[C:14]([CH3:17])[C:15]=3[CH3:16])=[C:6]2[N:5]=[CH:4][N:3]=1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 178431898HCID 178431898, compound

Product 1

HCID 67797825HCID 67797825, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a mixture of 4-hydroxy-8-(3-methyl-4-methylthiophenyl)pyrazolo[1,5-a]-1,3,5-triazine (0.100 g), triethylamine (0.1 ml) and methylene chloride (10 ml) is added dropwise acetyl chloride (0.1 ml) at room temperature. After reacting for 10 minutes, to the reaction mixture is added methylene chloride (90 ml). The mixture is washed with water (20 ml×3), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (0.110 g).

Workup

  1. washThe mixture is washed with water (20 ml×3)
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7c4153eb7b8b4008ac4a2866c0164fd9
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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