Hydrochloric Acid → HCID 178435090, compound

HRID 621658Notes

Reaction equation

HRID 621658 reaction equation
[NH2:1][C:2]1[C:6]([C:7]2[C:11]([CH3:12])=[C:10]([CH3:13])[S:9][C:8]=2[F:14])=[CH:5][NH:4][N:3]=1.[C:15](=[O:20])=[N:16][C:17](Cl)=[O:18].Cl>N1C=CC=CC=1>[OH:20][C:15]1[N:16]=[C:17]([OH:18])[N:3]2[N:4]=[CH:5][C:6]([C:7]3[C:11]([CH3:12])=[C:10]([CH3:13])[S:9][C:8]=3[F:14])=[C:2]2[N:1]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 119708Isocyanatocarbonyl chlorideHCID 178435089HCID 178435089, compound

Product 1

HCID 178435090HCID 178435090, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
0 °C

Procedure

3-Amino-4-(2-fluoro-5-methyl-4-methylthiophenyl)pyrazole (2.74 g) is dissolved in pyridine (20 ml) and the mixture is cooled to 0° C. To the mixture is added N-(chlorocarbonyl)isocyanate (1.03 ml), and the mixture is stirred at room temperature for 4 hours. The reaction mixture is acidified by adding thereto 10% hydrochloric acid under ice cooling. The resulting precipitate is separated by filtration, washed with water and dried to give the title compound (3.4 g).

Workup

  1. additionby adding
  2. customThe resulting precipitate is separated by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-99c4dff1d2f14bcab38c63d11c8dfc6b
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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