HCID 178487646, compound → HCID 178487647, compound

HRID 621659Notes

Reaction equation

HRID 621659 reaction equation
[OH2:1].[OH:2][C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[O:19])=[C:14]([O:26][CH3:27])[CH:13]=3)=[C:7]2[N:6]=[CH:5][N:4]=1>CN(C)C=O>[OH2:2].[OH2:1].[OH:2][C:3]1[N:8]2[N:9]=[CH:10][C:11]([C:12]3[CH:17]=[CH:16][C:15]([S:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[O:19])=[C:14]([O:26][CH3:27])[CH:13]=3)=[C:7]2[N:6]=[CH:5][N:4]=1

Participants

3

Reactant 1

HCID 178487646HCID 178487646, compound

Product 1

HCID 178487647HCID 178487647, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Hydroxy-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine monohydrate (80 g) is dissolved in N,N-dimethylformamide (600 ml), and the insoluble material is filtered off. To the filtrate is added water (3 liters), and the resulting precipitate is separated by filtration and refluxed in acetone (1.6 liter) for 2 hours. After cooling, the precipitate is separated by

Workup

  1. filtrationthe insoluble material is filtered off
  2. additionTo the filtrate is added water (3 liters)
  3. customthe resulting precipitate is separated by filtration
  4. temperaturerefluxed in acetone (1.6 liter) for 2 hours
  5. temperatureAfter cooling
  6. customthe precipitate is separated by

Sources & evidence

ORD record
ord-0f8836e601dd40d7976f2cdf2703ad6b
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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