HCID 178487647, compound → HCID 178487645, compound

HRID 621660Notes

Reaction equation

HRID 621660 reaction equation
O.O.[OH:3][C:4]1[N:9]2[N:10]=[CH:11][C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:20])=[C:15]([O:27][CH3:28])[CH:14]=3)=[C:8]2[N:7]=[CH:6][N:5]=1>C(OCC)(=O)C>[OH:3][C:4]1[N:9]2[N:10]=[CH:11][C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:20])=[C:15]([O:27][CH3:28])[CH:14]=3)=[C:8]2[N:7]=[CH:6][N:5]=1

Participants

3

Reactant 1

HCID 178487647HCID 178487647, compound

Product 1

HCID 178487645HCID 178487645, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4-Hydroxy-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine dihydrate (15 g) is suspended in ethyl acetate (450 ml), and the mixture refluxed for 3 hours. After cooling, the precipitate is separated by filtration and is again suspended in ethyl acetate (400 ml), and the mixture is refluxed for 3 hours. After cooling, the precipitate is separated by filtration and dried under reduced pressure at 120° C. for 50 hours to give the title compound (13.7 g).

Workup

  1. temperaturethe mixture refluxed for 3 hours
  2. temperatureAfter cooling
  3. customthe precipitate is separated by filtration
  4. temperaturethe mixture is refluxed for 3 hours
  5. temperatureAfter cooling
  6. customthe precipitate is separated by filtration
  7. customdried under reduced pressure at 120° C. for 50 hours

Sources & evidence

ORD record
ord-25e6a55d277d4cfbad0181c452bd2ed0
Source dataset
uspto-grants-1989_04
Patent number
US04824834

Reaction notes

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