HRID621665

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID637090

(E)-Crotonic acid

C4H6O2

结构：O=C(c1ccccc1)c1ccc(OCC(O)COc2ccc(C(=O)c3ccccc3)c(O)c2)cc1O

HCID1242235

[4-[3-(4-benzoyl-3-hydroxyphenoxy)-2-hydroxypropoxy]-2-hydroxyphenyl]-phenylmethanone

C29H24O7

PRODUCTS

生成物

结构：C/C=C/C(=O)OC(COc1ccc(C(=O)c2ccccc2)c(O)c1)COc1ccc(C(=O)c2ccccc2)c(O)c1

HCID70395005

未命名化合物

收率 75.1%

PROCEDURE

实验过程

97 g (0.2 mole) of 1,3-bis-(4-benzoyl-3-hydroxyphenoxy)-2-propanol were esterified analogously to Example 1 with 103 g (1.2 moles) of crotonic acid. After crystallization from an acetone/ethanol mixture (ratio by volume 1:2), 83 g (75 percent of theory) of 1,3-bis-(4-benzoyl-3-hydroxyphenoxy)-prop-2-yl crotonate were obtained in the form of fine white crystals having a melting point of 99° to 103° C. and a purity of 99 percent (HPLC). The structure of the compound obtained was confirmed by UV, IR and NMR spectra.

WORKUP

后处理

customAfter crystallization from an acetone/ethanol mixture (ratio by volume 1:2)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c9e574ae262349eb8989caac247896ee
来源数据集: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04824892
来源说明: uspto-grants-1989_04

反应 SMILES

[C:1]([C:9]1[CH:35]=[CH:34][C:12]([O:13][CH2:14][CH:15]([OH:33])[CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24](=[O:31])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[C:20]([OH:32])[CH:19]=2)=[CH:11][C:10]=1[OH:36])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:37](O)(=[O:41])/[CH:38]=[CH:39]/[CH3:40]>>[C:37]([O:33][CH:15]([CH2:14][O:13][C:12]1[CH:34]=[CH:35][C:9]([C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[C:10]([OH:36])[CH:11]=1)[CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24](=[O:31])[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[C:20]([OH:32])[CH:19]=1)(=[O:41])/[CH:38]=[CH:39]/[CH3:40]