Hydrogen Bromide → 6-(Aminomethyl)pyridin-2(1H)-one hydrobromide

HRID 621701Notes

Reaction equation

HRID 621701 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9]C)[N:4]=1.[BrH:11]>>[BrH:11].[NH2:1][CH2:2][C:3]1[NH:4][C:5](=[O:9])[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 13882973(6-Methoxypyridin-2-yl)methanamine

Product 1

HCID 135635896-(Aminomethyl)pyridin-2(1H)-one hydrobromide

Procedure

The crude product from Example 2 was combined with 10 ml of 48% hydrobromic acid, and the resulting mixture was heated at its reflux temperature for one hour. Evaporation to dryness provided 6-aminomethyl-2(1H)-pyridone hydrobromide as a water-soluble solid. The structural assignment was supported by infrared and nuclear magnetic resonance spectral analyses.

Workup

  1. temperaturethe resulting mixture was heated at its
  2. temperaturereflux temperature for one hour
  3. customEvaporation to dryness

Sources & evidence

ORD record
ord-47e58c360f1340b29ab0ce87a69d3ccb
Source dataset
uspto-grants-1989_04
Patent number
US04824953

Reaction notes

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