2-Bromopropane → HCID 14154270, compound

HRID 621802Notes

Reaction equation

HRID 621802 reaction equation
[Br:1][C:2]1[C:3]([OH:20])=[C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]=1[Br:7].[CH3:21][C:22](C)([O-])[CH3:23].[K+].BrC(C)C>>[Br:1][C:2]1[C:3]([O:20][CH:22]([CH3:23])[CH3:21])=[C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]=1[Br:7]

Participants

4

Reactant 3

HCID 63582-BromopropaneHCID 23665647Potassium tert-butoxideHCID 54697140HCID 54697140, compound

Product 1

HCID 14154270HCID 14154270, compoundYield 84.2%

Procedure

Prepared using the method described in Example 107 from ethyl 4,5-dibromo-3-hydroxy-1-(phenylmethyl)-1H-pyrrole-2-carboxylate (3.2 g, 0.008 moles), potassium tert-butoxide (1.0 g, 0.009 moles) and 2-bromopropane (2.0 g, 0.016 moles). The product crystallized upon aqueous workup and was filtered off, rinsed with water and dried to afford the pure product (3.0 g); mp 46°-48° C.

Workup

  1. customPrepared
  2. customThe product crystallized upon aqueous workup
  3. filtrationwas filtered off
  4. washrinsed with water
  5. customdried

Sources & evidence

ORD record
ord-7b77e25e6b27406895ffd7401e8e1066
Source dataset
uspto-grants-1989_04
Patent number
US04824958

Reaction notes

Loading…