1,1'-Carbonyldiimidazole → HCID 178458735, compound

HRID 621810Notes

Reaction equation

HRID 621810 reaction equation
[Br:1][C:2]1[C:3]([O:11][CH:12]([CH3:14])[CH3:13])=[C:4]([C:8](O)=[O:9])[NH:5][C:6]=1[Br:7].C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:27][C:28]1[NH:32][N:31]=[N:30][N:29]=1>>[Br:1][C:2]1[C:3]([O:11][CH:12]([CH3:14])[CH3:13])=[C:4]([C:8]([NH:27][C:28]2[NH:32][N:31]=[N:30][N:29]=2)=[O:9])[NH:5][C:6]=1[Br:7]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 14873720HCID 14873720, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178458735HCID 178458735, compoundYield 19%

Procedure

Prepared by the method described in Example 115 from 4,5-dibromo-3-(1-methylethoxy)-1H-pyrrole-2-carboxylic acid (1.4 g, 0.004 moles), 1,1'-carbonyldiimidazole (1.2 g, 0.007 moles), and 5-aminotetrazole (0.6 g, 0.007 moles). Recrystallization from acetonitrile gave the product (0.3 g); mp 194°-196° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-da953824fa7d4fd2b5482109ea09148a
Source dataset
uspto-grants-1989_04
Patent number
US04824958

Reaction notes

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