Benzoic Acid → 8-Phenyl-1,3-dipropyl-3,9-dihydro-1H-purine-2,6-dione

HRID 622082Notes

Reaction equation

HRID 622082 reaction equation
[CH2:1]([N:4]1[C:11]([NH2:12])=[C:10]([NH2:13])[C:8](=[O:9])[N:7]([CH2:14][CH2:15][CH3:16])[C:5]1=[O:6])[CH2:2][CH3:3].[C:17](O)(=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CO>[CH2:14]([N:7]1[C:8](=[O:9])[C:10]2[NH:13][C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:12][C:11]=2[N:4]([CH2:1][CH2:2][CH3:3])[C:5]1=[O:6])[CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 243Benzoic AcidHCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 1287848-Phenyl-1,3-dipropyl-3,9-dihydro-1H-purine-2,6-dioneYield 77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1,3-dipropyl-5,6-diaminouracil (0.01 mol) was dissolved in 30 ml methanol, followed by 0.01 mol of benzoic acid and then 0.01 mol of DICD. The solution was stirred for 30 min at room temperature, filtered, and washed with a small amount of methanol. The solid was boiled for ten minutes in 2.5N KOH, filtered hot, and the liquid neutralized with concentrated HCl. The solid was collcted by filtration, washed with water, redissolved in 100 ml with a minimum amount of KOH, precipitated by neutralization with HCl, filtered, washed with water, and dried. The product was identified by chemical ionization mass spectrometry and elemental Analysis. Yield 77%.

Workup

  1. filtrationfiltered
  2. washwashed with a small amount of methanol
  3. waitThe solid was boiled for ten minutes in 2.5N KOH
  4. filtrationfiltered hot
  5. filtrationThe solid was collcted by filtration
  6. washwashed with water
  7. dissolutionredissolved in 100 ml with a minimum amount of KOH
  8. customprecipitated by neutralization with HCl
  9. filtrationfiltered
  10. washwashed with water
  11. customdried

Sources & evidence

ORD record
ord-2fdb30d8c4e14c329e0fc9b5b224ddba
Source dataset
uspto-grants-1988_09
Patent number
US04769377

Reaction notes

Loading…