Ammonia → HCID 13770127, compound

HRID 622086Notes

Reaction equation

HRID 622086 reaction equation
CC1O[C:4]2([N:25]3[CH2:30][CH2:29]OCC3)[CH:9]([CH:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21]([F:24])([F:23])[F:22])[C:11]=1[N+:12]([O-:14])=[O:13])[CH2:8][CH2:7][CH2:6][CH2:5]2.N.Cl>C(O)C.O>[CH3:29][C:30]1[NH:25][C:4]2[CH2:5][CH2:6][CH2:7][CH2:8][C:9]=2[CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:21]([F:23])([F:22])[F:24])[C:11]=1[N+:12]([O-:14])=[O:13]

Participants

6

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 13770134HCID 13770134, compound

Product 1

HCID 13770127HCID 13770127, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

2 g (4.7 mmol) of 2-methyl-8a-morpholino-3-nitro-4-(2-trifluoromethylphenyl)-4a,5,6,7,8,8a-hexahydro-4H-chromene are suspended in 15 ml of ethanol and dissolved with about 3 ml of concentrated aqueous ammonia solution at 30° to 45° C. The pH is then brought to 3 with concentrated hydrochloric acid and the solution is diluted with 5 ml of water and extracted twice with 10 ml of chloroform each time. After the chloroform has been evaporated off, the residue crystallizes in yellow crystals from a little ethanol.

Workup

  1. extractionextracted twice with 10 ml of chloroform each time
  2. customAfter the chloroform has been evaporated off
  3. customthe residue crystallizes in yellow crystals from a little ethanol

Sources & evidence

ORD record
ord-86d07e316d734974bf3e4f7bf313c34a
Source dataset
uspto-grants-1988_09
Patent number
US04769375

Reaction notes

Loading…