Diethylamine → HCID 15068658, compound

HRID 622091Notes

Reaction equation

HRID 622091 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[CH2:9]([NH:11][CH2:12][CH3:13])[CH3:10]>C(OCC)C>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([N:11]([CH2:12][CH3:13])[CH2:9][CH3:10])=[CH:4][CH2:3]1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 740491-Methyl-4-piperidone

Product 1

HCID 15068658HCID 15068658, compoundYield 59.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The starting substance is prepared as follows: To 1000 g of Klinosorb-4 molecular sieve 1000 ml of dry diethyl ether, 226 g of 1-methyl-4-piperidone and 219 g of dry diethylamine are added. The reaction mixture is kept at room temperature for 4 days and then filtered off. The Klinosorb-4 is washed with ether, the filtrate and the washing are combined, the solvent is distilled off and the residue is purified by distillation in vacuo to give 1-methyl-4-diethylamino-1,2,5,6-tetrahydropyridine with a yield of 59.9%, bp.: 88°-106° C./1.5 kPa; nD20 =1.4825.

Workup

  1. customThe starting substance is prepared
  2. filtrationfiltered off
  3. washThe Klinosorb-4 is washed with ether
  4. distillationthe solvent is distilled off
  5. distillationthe residue is purified by distillation in vacuo

Sources & evidence

ORD record
ord-3d503d76569046f7b58e694844a7da86
Source dataset
uspto-grants-1988_09
Patent number
US04769373

Reaction notes

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