HCID 17846762, compound → HCID 21293331, compound

HRID 622132Notes

Reaction equation

HRID 622132 reaction equation
Br.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[C:18](=[O:22])[N:17]([CH2:23][CH2:24]N(C)C)[N:16]=[CH:15]3)=[CH:6][CH:5]=1.[Br:28]C1C=C2C(=CC=1)C(=O)N(CC[CH2:42][N:43]([CH3:45])[CH3:44])N=C2.BrC1C=C2C(=CC=1)C(=O)N(CCN(C)C)N=C2>>[BrH:28].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[C:18](=[O:22])[N:17]([CH2:23][CH2:24][CH2:42][N:43]([CH3:45])[CH3:44])[N:16]=[CH:15]3)=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 17846762HCID 17846762, compoundHCID 21293332HCID 21293332, compoundHCID 21293346HCID 21293346, compound

Product 1

HCID 21293331HCID 21293331, compound

Procedure

The procedure used was identical to that used in preparing 6-[2-(4-methoxyphenyl)ethenyl]-2-[2-(dimethylamino)ethyl]phthalazin-1(2H)-one (Example III above), except that 6-Bromo-2-[3-(dimethylamino)propyl]phthalazin-1(2H)-one was substituted for 6-Bromo-2-[2-(dimethyamino)ethyl]phthalazin-1(2H)-one. The weight of product obtained from 102 gm starting halide was 104 gm after recrystallization from 50 ml of methoxyethanol. It melted at 232°-234° C.

Workup

  1. customThe weight of product obtained from 102 gm
  2. customafter recrystallization from 50 ml of methoxyethanol

Sources & evidence

ORD record
ord-53174ac763514d21a54b40c4374b1270
Source dataset
uspto-grants-1988_09
Patent number
US04769369

Reaction notes

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